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KMID : 0613820140240010067
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Journal of Life Science
2014 Volume.24 No. 1 p.67 ~ p.73
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Opuntia humifusa Supplementation Reduces Fat Weight by Increasing PPAR-γ and PGC-1α Protein Expression in the Skeletal Muscle of Rats
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Kwon Dae-Keun
Kang Jun-yong
Kim Jae-seung
Song Young-Ju
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Abstract
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This study was conducted to investigate the effects of supplementation with Opuntia humifusa on the expression of peroxisome proliferator-activated receptor-delta (PPAR-δ), peroxisome proliferator-activated receptor-gamma (PPAR-r) and peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α) in the skeletal muscle of rats fed a high-fat diet. Sixteen Sprague-Dawley male rats at 6 weeks of age were randomly divided into 2 groups: a control diet group (CG, n=8) and an experimental diet group (EG, n=8). The rats were fed a high-fat diet (CG) or a high-fat diet supplemented with 5% O. humifusa (EG) for 8 weeks. The results showed that the abdominal fat pad and epididymal fat pad weights were significantly lower in the EG than in the CG (p<0.01). In the blood, serum glucose, triglycerides, and total cholesterol in the EG group were lower than in the CG (p<0.01). The expression of PPAR-r and PGC-1α protein in the skeletal muscle of the EG was increased compared with that of the CG (p<0.05). These results indicate that 8 weeks of O. humifusa supplementation lowers serum glucose and triglyceride levels and suppresses weight gain by reducing fat weight through an increase in the expression of PPAR-r and PGC-1α in the muscle tissue of rats.
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KEYWORD
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High-fat diet, Opuntia humifusa, PPAR-δ, PPAR-r, PGC-1α
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